Fresh analysis reveals that individuals who stop using blockbuster GLP-1 drugs like Mounjaro or Wegovy can put back on lost weight far faster than those who stop conventional diet and exercise plans.
Research printed in a major medical journal demonstrates that while obese individuals often shed about a fifth of their body weight while on the medication, the mass comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Users buying such medications must be informed of the potential of quick weight regain when the treatment concludes," cautioned researcher Dr. Susan Jebb.
Such speed of recovery implies a reversion to original mass in about 18 months.
Analyzing Therapies
The research, which reviewed dozens of studies involving over 9,000 of participants, contrasted the effects of the injectable medications with other pills.
Researchers note that individuals who shed pounds through dieting usually have a more gradual creep back—approximately 100 grams monthly—once they finish.
The Reason for the Fast Rebound
Nutrition scientists propose the mechanism of the injections is key to understanding the heightened rebound.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Artificially providing GLP-1 levels far above than the body's typical production might result in the system to produce less of its own natural GLP-1, and may also diminish responsiveness to its effects," said Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication leads to appetite is unsuppressed, making overeating far more likely."
A Chronic Disease?
Medical guidelines recommend the injections for individuals with weight-linked health risks, accompanied by recommended diet and exercise modifications.
Professionals contend that, due to the significant potential of weight regain, the therapy might need to be life-long.
This perspective is supported by pharmaceutical companies, who state that the findings "underscore the persistent nature of excess weight," similar to managing diseases like hypertension.
User Testimonies
Users who have come off the jabs explain a sudden return of appetite.
"I experienced a switch flipping and you become starving," said a patient.
The struggle is exacerbated if individuals have not developed permanent dietary or behavioural changes during therapy.
Significant Use
Recent estimates indicate that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with interest being substantial.
- Use is more common among women compared to men.
- The 40s and 50s age group shows the greatest level of interest.
- Many obtain the medications through private prescriptions rather than the NHS.
In conclusion, experts stress that while GLP-1 drugs are potent agents for weight loss, they are not a standalone cure and long-term success relies on integrated lifestyle support.
